Anti-inflammatory agent 35

Research use only, not for human use.

Anti-inflammatory agent 35 is a potent anti-inflammatory agent.

Anti-inflammatory agent 35 (compound 5a27) is an orally active curcumin analogue with anti-inflammatory activity. Anti-inflammatory agent 35 blocks mitogen-activated protein kinase (MAPK) signaling and p65 nuclear translocation of NF-kB. Anti-inflammatory agent 35 also inhibits yellow neutrophil infiltration and pro-inflammatory cytokine production. Anti-inflammatory agent 35 significantly attenuates lipopolysaccharide (LPS)-induced acute lung injury (ALI) in vivo.

Western Blot Analysis Cell Line:RAW 264.7 mouse macrophages Concentration:10 μM Incubation Time:30 min; followed by incubation with 0.5 μg/mL LPS for another 30 min Result:Decreased the phosphorylation of p38 and ERK. And down-regulated IκB (inhibitor of NF-κB), inhibits the transcription of TNF-α, IL-6, IL-1β, ICAM-1.

Animal Model:ALI mouse model (C57BL/6 mice)Dosage:10 mg/kg Administration:Intraperitoneal injection, once daily for 1 week; 30 min later every dose, followed by 5 mg/kg LPS, intratracheal injection Result:Significantly normalized the wet/dry ratio of lungs.

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Others

Other Targets

Immunology/Inflammation related

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2293951-00-3

495.52

C27H29NO8

>98% (HPLC)

In Vitro:?DMSO : 16.67 mg/mL (33.64 mM; Ultrasonic (<60°C)

COc1cc(\C=C\C(=O)N2CCC\C(=C/c3cc(OC)c(OC)c(OC)c3)C2=O)ccc1OC(C)=O

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(-20℃)

With Ice Pack

≥ 2 years